Almost two months of resurfacing and maintenance on the A339 through Newbury is set to start on Monday.
It starts with the installation of police bays and the cutting back of vegetation between the Burger King roundabout and Pinchington Lane, which will see nearside lane closures on weekdays from 9.30am to 3.30pm until September 4.
That will be followed with resurfacing of the same stretch from September 5.
Lane closures will in force for 13 nights between 7pm and 11.30pm, missing out one evening on September 8 to avoid a clash with the Greenham Common anniversary celebrations.
Next Tuesday work is also set to start on drainage improvements and vegetation cutting between the Robin Hood roundabout and the Vodafone roundabout.
There will be lane closures between 9.30am and 3.30pm on weekdays and 7am to 1pm on Saturdays for a total of 19 days.
The same stretch will then be resurfaced for 10 nights from October 2, with a complete road closure in force from 7pm to 5.30am Mondays to Fridays. Diversions will be in place.
A statement from West Berkshire Council said: “The works are part of the Government’s £5.6million grant awarded by the Department for Transport in 2015 for maintenance of the A339.
“The works will take place off peak during the day and in the evenings to minimise disruption.”